May increase effect of levodopa, dopaminergic agonists & anticholinergics; reduce effect of barbiturates & neuroleptics. Concomitant use w/ antispasmodic agents, dantrolene or baclofen. Increased risk of pharmacotoxic psychosis w/ amantadine, ketamine, dextromethorphan & phenytoin. May increase plasma levels w/ cimetidine, ranitidine, procainamide, quinidine, quinine & nicotine. May reduce serum level of hydrochlorothiazide. May increase INR w/ oral anticoagulants eg, warfarin.